2nd Wednesday of every month | 4:00-5:00pm | 1195 Starzl BST, Univ of Pitt
The Pitt Microbiome Seminar, held at the University of Pittsburgh campus, helps form collaborations across the Pittsburgh area and presents opportunities for more advanced microbiome research. Previous microbiome experience is not required, and all degree levels are welcome.
There are no meetings scheduled at this time.
Please contact Cindy Vinkovich for more information.
- JANUARY 9, 2019 Immunometabolism and Staphylococcus Aureus Infections Anthony Richardson, PhD Associate Professor of Microbiology & Molecular Genetics University of Pittsburgh School of Medicine
- FEBRUARY 13, 2019 Microbiota-mediated triggers of gut barrier dysfunction Reinhard Hinterleitner, PhD Assistant Professor, Department of Immunology University of Pittsburgh School of Medicine
- MARCH 13, 2019 Riboregulation in Innate Immunity and Inflammation Maninjay Atianand, PhD Assistant Professor, Department of Immunology University of Pittsburgh School of Medicine
Cellular behaviors are governed by dynamic gene expression programs regulated at both the transcriptional and post-transcriptional level. However, our understanding of the gene regulatory mechanisms is far from complete. In this talk, I will discuss the role of RNA-dependent gene regulation in innate immunity and inflammation with a focus on the role of long noncoding RNAs in macrophage inflammatory response.
- APRIL 10, 2019 Proto-genes and De Novo Gene Birth Anne-Ruxandra Carvunis, PhD Assistant Professor, Department of Computational and Systems Biology University of Pittsburgh School of Medicine
- MAY 8, 2019 Discovering molecular links along the gut-microbiome-brain-physiology axis in the fruit fly, Drosophila melanogaster Brooke McCartney, PhD Associate Professor, Department of Biological Sciences Carnegie Mellon University
- JUNE 12, 2019 Quantitative control of macrophage signaling by lung-specific stimuli Rachel A. Gottschalk, PhD Assistant Professor, Department of Immunology University of Pittsburgh School of Medicine
Innate immune signaling must be tightly regulated to support robust protective inflammatory responses to infection, while avoiding inflammation upon minor challenges. A fundamental challenge in inflammation research is to understand how signals are modulated to facilitate quantitative decision-making within cells.Quantitative trait loci for kinase and phosphatase genes have been linked with chronic inflammatory diseases of barrier sites, suggesting that modest expression changes in signaling components contribute to aberrant inflammation in humans. Changes in microbiota composition and other environmental factors are also associated with chronic inflammation in barrier tissues. A major focus of our lab is elucidating mechanisms supporting distinct regulation of macrophage signaling in the lung. Our current efforts include investigation of environmental factors that control lung-specific homeostatic cytokine expression, alveolar macrophage signaling proteins regulated by homeostatic cytokines, and mechanisms by which these proteins tune alveolar macrophage signaling and function. Understanding regulation and dysregulation of these processes will inform mechanistic links between disease-associated genetic factors, changes in the microbiota, and inflammatory disease development.
- SEPTEMBER 11, 2019 Host-microbiome Interactions in Liver Disease Marlies Meisel, PhD Assistant Professor, Department of Immunology University of Pittsburgh School of Medicine
Chronic inflammatory liver disease is a major public health issue and is the 12th leading cause of death in the US. Despite major advances in the field, a clear understanding of which individuals are at risk to develop liver disease remains elusive and few effective therapies exist. Hepatic inflammation sets the stage of overt liver disease and the gut microbiota is a key player in liver pathologies. We are studying mechanisms how the gut microbiota impacts on the development of hepatic pathology by modulating hepatic immune responses.
- NOVEMBER 13, 2019
Emergent host adaptation within generation, mediated by newly-forming variations in gut microbiota
Prof. Yoav Soen
Associate Professor, Department of Molecular Biosciences
- DECEMBER 11, 2019
Tapping into the Sources of Opportunistic Bacterial Pulmonary Infections in Children with Cystic Fibrosis
Dr. Sarah Haig
Associate Professor, Department of Civil & Environmental Engineering and Graduate School of Public Health
University of Pittsburgh
- JANUARY 8, 2020
Acne’s Impact on Immunotherapy – how understanding an “acne cure” could help us treat melanoma
William Howard McCoy IV, MD, PhD
Instructor in Medicine, Internal Medicine, Dermatology
Washington University in St. Louis
- DATE TBD
Bad to the Bone – Biofilm and Orthopaedic Infection
Ken Urish, MD, PhD
Assistant Professor, Department of Orthopaedic Surgery
University of Pittsburgh School of Medicine