2024

Hartman TJ, Christie J, Wilson A, Ziegler TR, Methe B, Flanders WD, Rolls BJ, Loye Eberhart B, Li JV, Huneault H, Cousineau B, Perez MR, O’Keefe SJD. Fibre-rich Foods to Treat Obesity and Prevent Colon Cancer trial study protocol: a randomised clinical trial of fibre-rich legumes targeting the gut microbiome, metabolome and gut transit time of overweight and obese patients with a history of noncancerous adenomatous polyps. BMJ Open. 2024 Feb 5;14(2):e081379. doi: 10.1136/bmjopen-2023-081379. PMID: 38316601; PMCID: PMC10860035.
Rogers MB, Harner A, Buhay M, Firek B, Methé B, Morris A, Palmer OMP, Promes SB, Sherwin RL, Southerland L, Vieira AR, Yende S, Morowitz MJ, Huang DT. The salivary microbiota of patients with acute lower respiratory tract infection-A multicenter cohort study. PLoS One. 2024 Jan 11;19(1):e0290062. doi: 10.1371/journal.pone.0290062. PMID: 38206940; PMCID: PMC10783762.

2023

Kitsios GD, Sayed K, Fitch A, Yang H, Britton N, Shah F, Bain W, Evankovich JW, Qin S, Wang X, Li K, Patel A, Zhang Y, Radder J, Cruz CD, Okin DA, Huang CY, van Tyne D, Benos PV, Methé B, Lai P, Morris A, McVerry BJ. Prognostic Insights from Longitudinal Multicompartment Study of Host-Microbiota Interactions in Critically Ill Patients. Res Sq [Preprint]. 2023 Sep 26:rs.3.rs-3338762. doi: 10.21203/rs.3.rs-3338762/v1. PMID: 37841841; PMCID: PMC10571606.

Dunlap DG, Yang L, Qin S, Li K, Fitch A, Huang L, McVerry BJ, Hand TW, Methé BA, Morris A. Magnetic-activated cell sorting identifies a unique lung microbiome community. Microbiome. 2023 May 25;11(1):117. doi: 10.1186/s40168-022-01434-5. PMID: 37226179; PMCID: PMC10210470.

Kitsios GD, Nguyen VD, Sayed K, Al-Yousif N, Schaefer C, Shah FA, Bain W, Yang H, Fitch A, Li K, Wang X, Qin S, Gentry H, Zhang Y, Varon J, Arciniegas Rubio A, Englert JA, Baron RM, Lee JS, Methé B, Benos PV, Morris A, McVerry BJ. The upper and lower respiratory tract microbiome in severe aspiration pneumonia. iScience. 2023 May 6;26(6):106832. doi: 10.1016/j.isci.2023.106832. PMID: 37250794; PMCID: PMC10212968.

Heinrich VA, Uvalle C, Manni ML, Li K, Mullett SJ, Donepudi SR, Clader J, Fitch A, Ellgass M, Cechova V, Qin S, Holguin F, Freeman BA, Methé BA, Morris A, Gelhaus SL. Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma. Front Microbiomes. 2023;2:1153691. doi: 10.3389/frmbi.2023.1153691. Epub 2023 May 5. PMID: 37293566; PMCID: PMC10249466.

2022

Tonelli Enrico V, Vo N, Methe B, Morris A, Sowa G. An unexpected connection: A narrative review of the associations between Gut Microbiome and Musculoskeletal Pain. Eur Spine J. 2022 Dec;31(12):3603-3615. doi: 10.1007/s00586-022-07429-y. Epub 2022 Oct 29. PMID: 36308543; PMCID: PMC9617047.

Li K, Methé BA, Fitch A, Gentry H, Kessinger C, Patel A, Petraglia V, Swamy P, Morris A. Gut and oral microbiota associations with viral mitigation behaviors during the COVID-19 pandemic. Front Cell Infect Microbiol. 2022 Sep 9;12:966361. doi: 10.3389/fcimb.2022.966361. PMID: 36159641; PMCID: PMC9500509.

Armbruster CR, Li K, Kiedrowski MR, Zemke AC, Melvin JA, Moore J, Atteih S, Fitch AC, DuPont M, Manko CD, Weaver ML, Gaston JR, Alcorn JF, Morris A, Methé BA, Lee SE, Bomberger JM. Low Diversity and Instability of the Sinus Microbiota over Time in Adults with Cystic Fibrosis. Microbiol Spectr. 2022 Oct 26;10(5):e0125122. doi: 10.1128/spectrum.01251-22. Epub 2022 Sep 12. PMID: 36094193; PMCID: PMC9603634.

Muhoozi GKM, Li K, Atukunda P, Skaare AB, Willumsen T, Enersen M, Westerberg AC, Morris A, Vieira AR, Iversen PO, Methé BA. Child saliva microbiota and caries: a randomized controlled maternal education trial in rural Uganda. Sci Rep. 2022 May 12;12(1):7857. doi: 10.1038/s41598-022-11979-y. PMID: 35552492; PMCID: PMC9098507.

2021

Chen Y, Lin H, Cole M, Morris A, Martinson J, Mckay H, Mimiaga M, Margolick J, Fitch A, Methe B, Srinivas VR, Peddada S, Rinaldo CR. Signature changes in gut microbiome are associated with increased susceptibility to HIV-1 infection in MSM. Microbiome. 2021 Dec 9;9(1):237. doi: 10.1186/s40168-021-01168-w. PMID: 34879869; PMCID: PMC8656045.

Alder JK, Sutton RM, Iasella CJ, Nouraie M, Koshy R, Hannan SJ, Chan EG, Chen X, Zhang Y, Brown M, Popescu I, Veatch M, Saul M, Berndt A, Methé BA, Morris A, Pilewski JM, Sanchez PG, Morrell MR, Shapiro SD, Lindell KO, Gibson KF, Kass DJ, McDyer JF. Lung transplantation for idiopathic pulmonary fibrosis enriches for individuals with telomere-mediated disease. J Heart Lung Transplant. 2022 May;41(5):654-663. doi: 10.1016/j.healun.2021.11.008. Epub 2021 Nov 15. PMID: 34933798; PMCID: PMC9038609.

Armbruster CR, Marshall CW, Garber AI, Melvin JA, Zemke AC, Moore J, Zamora PF, Li K, Fritz IL, Manko CD, Weaver ML, Gaston JR, Morris A, Methé B, DePas WH, Lee SE, Cooper VS, Bomberger JM. Adaptation and genomic erosion in fragmented Pseudomonas aeruginosa populations in the sinuses of people with cystic fibrosis. Cell Rep. 2021 Oct 19;37(3):109829. doi: 10.1016/j.celrep.2021.109829. PMID: 34686349; PMCID: PMC8667756.

Li K, Epperly MW, Barreto GA, Greenberger JS, Methé BA. “Longitudinal Fecal Microbiome Study of Total Body Irradiated Mice Treated With Radiation Mitigators Identifies Bacterial Associations With Survival”. Front Cell Infect Microbiol. 2021 Sep 21;11:715396. doi: 10.3389/fcimb.2021.715396. PMID: 34621689; PMCID: PMC8490782.

Kitsios GD, Kotok D, Yang H, Finkelman MA, Zhang Y, Britton N, Li X, Levochkina MS, Wagner AK, Schaefer C, Villandre JJ, Guo R, Evankovich JW, Bain W, Shah F, Zhang Y, Methé BA, Benos PV, McVerry BJ, Morris A. Plasma 1,3-β-d-glucan levels predict adverse clinical outcomes in critical illness. JCI Insight. 2021 Jul 22;6(14):e141277. doi: 10.1172/jci.insight.141277. PMID: 34128840; PMCID: PMC8410081.

Jawale CV, Li DD, Ramani K, Lin L, Li K, Methe B, Biswas PS. Uremia Coupled with Mucosal Damage Predisposes Mice with Kidney Disease to Systemic Infection by Commensal Candida albicans. Immunohorizons. 2021 Jan 15;5(1):16-24. doi: 10.4049/immunohorizons.2000114. PMID: 33451988; PMCID: PMC7913778.

Stapleton AL, Shaffer AD, Morris A, Li K, Fitch A, Methé BA. The microbiome of pediatric patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2021 Jan;11(1):31-39. doi: 10.1002/alr.22597. Epub 2020 Jun 22. PMID: 32348024.

Behari J, Graham L, Wang R, Schirda C, Borhani AA, Methé BA, Li K, Morris A, Luu HN, Palmieri S, Yuan JM. Dynamics of hepatic steatosis resolution and changes in gut microbiome with weight loss in nonalcoholic fatty liver disease. Obes Sci Pract. 2021 Jan 4;7(2):217-225. doi: 10.1002/osp4.476. PMID: 33841891; PMCID: PMC8019274.

2020

Kitsios GD, Yang H, Yang L, Qin S, Fitch A, Wang XH, Fair K, Evankovich J, Bain W, Shah F, Li K, Methé B, Benos PV, Morris A, McVerry BJ. Respiratory Tract Dysbiosis Is Associated with Worse Outcomes in Mechanically Ventilated Patients. Am J Respir Crit Care Med. 2020 Dec 15;202(12):1666-1677. doi: 10.1164/rccm.201912-2441OC. PMID: 32717152; PMCID: PMC7737572.

Reitz KM, Seymour CW, Vates J, Quintana M, Viele K, Detry M, Morowitz M, Morris A, Methe B, Kennedy J, Zuckerbraun B, Girard TD, Marroquin OC, Esper S, Holder-Murray J, Newman AB, Berry S, Angus DC, Neal M. Strategies to Promote ResiliencY (SPRY): a randomised embedded multifactorial adaptative platform (REMAP) clinical trial protocol to study interventions to improve recovery after surgery in high-risk patients. BMJ Open. 2020 Sep 29;10(9):e037690. doi: 10.1136/bmjopen-2020-037690. PMID: 32994242; PMCID: PMC7526307.

Dutta D, Li K, Methe B, Lim SH. Rifaximin on intestinally-related pathologic changes in sickle cell disease. Am J Hematol. 2020 Apr;95(4):E83-E86. doi: 10.1002/ajh.25722. Epub 2020 Feb 3. PMID: 31925798.

Yang L, Dunlap DG, Qin S, Fitch A, Li K, Koch CD, Nouraie M, DeSensi R, Ho KS, Martinson JJ, Methé B, Morris A. Alterations in Oral Microbiota in HIV Are Related to Decreased Pulmonary Function. Am J Respir Crit Care Med. 2020 Feb 15;201(4):445-457. doi: 10.1164/rccm.201905-1016OC. PMID: 31682463; PMCID: PMC7049920.

Ocvirk S, Wilson AS, Posma JM, Li JV, Koller KR, Day GM, Flanagan CA, Otto JE, Sacco PE, Sacco FD, Sapp FR, Wilson AS, Newton K, Brouard F, DeLany JP, Behnning M, Appolonia CN, Soni D, Bhatti F, Methé B, Fitch A, Morris A, Gaskins HR, Kinross J, Nicholson JK, Thomas TK, O’Keefe SJD. A prospective cohort analysis of gut microbial co-metabolism in Alaska Native and rural African people at high and low risk of colorectal cancer. Am J Clin Nutr. 2020 Feb 1;111(2):406-419. doi: 10.1093/ajcn/nqz301. PMID: 31851298; PMCID: PMC6997097.

2019

Yang L, Haidar G, Zia H, Nettles R, Qin S, Wang X, Shah F, Rapport SF, Charalampous T, Methé B, Fitch A, Morris A, McVerry BJ, O’Grady J, Kitsios GD. Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study. Respir Res. 2019 Nov 27;20(1):265. doi: 10.1186/s12931-019-1218-4. PMID: 31775777; PMCID: PMC6882222.

Castillo-Dela Cruz P, Wanek AG, Kumar P, An X, Elsegeiny W, Horne W, Fitch A, Burr AHP, Gopalakrishna KP, Chen K, Methé BA, Canna SW, Hand TW, Kolls JK. Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products. Cell Rep. 2019 Nov 19;29(8):2270-2283.e7. doi: 10.1016/j.celrep.2019.10.042. PMID: 31747600; PMCID: PMC6886715.

Fair K, Dunlap DG, Fitch A, Bogdanovich T, Methé B, Morris A, McVerry BJ, Kitsios GD. Rectal Swabs from Critically Ill Patients Provide Discordant Representations of the Gut Microbiome Compared to Stool Samples. mSphere. 2019 Jul 24;4(4):e00358-19. doi: 10.1128/mSphere.00358-19. PMID: 31341070; PMCID: PMC6656869.

Dutta D, Methe BA, Morris A, Lim SH. Effects of rifaximin on circulating aged neutrophils in sickle cell disease. Am J Hematol. 2019 Jun;94(6):E175-E176. doi: 10.1002/ajh.25467. Epub 2019 Apr 3. PMID: 30900765.

Dutta D, Methe B, Morris A, Lim SH. Elevated urinary 3-indoxyl sulfate in sickle cell disease. Am J Hematol. 2019 Jun;94(6):E162-E164. doi: 10.1002/ajh.25456. Epub 2019 Mar 20. PMID: 30851118.

Dutta D, Methe B, Amar S, Morris A, Lim SH. Intestinal injury and gut permeability in sickle cell disease. J Transl Med. 2019 May 30;17(1):183. doi: 10.1186/s12967-019-1938-8. PMID: 31146745; PMCID: PMC6543649.

2018

Lim SH, Methé BA, Knoll BM, Morris A, Obaro SK. Invasive non-typhoidal Salmonella in sickle cell disease in Africa: is increased gut permeability the missing link? J Transl Med. 2018 Aug 30;16(1):239. doi: 10.1186/s12967-018-1622-4. PMID: 30165857; PMCID: PMC6116559.

Lim SH, Morris A, Li K, Fitch AC, Fast L, Goldberg L, Quesenberry M, Sprinz P, Methé B. Intestinal microbiome analysis revealed dysbiosis in sickle cell disease. Am J Hematol. 2018 Aug;93(4):E91-E93. doi: 10.1002/ajh.25019. Epub 2018 Jan 9. PMID: 29274089.

Kitsios GD, Fitch A, Manatakis DV, Rapport SF, Li K, Qin S, Huwe J, Zhang Y, Doi Y, Evankovich J, Bain W, Lee JS, Methé B, Benos PV, Morris A, McVerry BJ. Respiratory Microbiome Profiling for Etiologic Diagnosis of Pneumonia in Mechanically Ventilated Patients. Front Microbiol. 2018 Jul 10;9:1413. doi: 10.3389/fmicb.2018.01413. PMID: 30042738; PMCID: PMC6048198.

Kitsios GD, Rojas M, Kass DJ, Fitch A, Sembrat JC, Qin S, Veraldi KL, Gibson KF, Lindell K, Pilewski JM, Methe B, Li K, McDyer J, McVerry BJ, Morris A. Microbiome in lung explants of idiopathic pulmonary fibrosis: a case-control study in patients with end-stage fibrosis. Thorax. 2018 May;73(5):481-484. doi: 10.1136/thoraxjnl-2017-210537. Epub 2017 Aug 11. PMID: 28802277; PMCID: PMC6850567.